Artificial adaptive systems

An individual patient is not the average representative of the population. Rather he or she is a person with unique characteristics. An intervention may be effective for a population but not necessarily for the individual patient. The recommendation of a guideline may not be right for a particular patient because it is not what he or she wants, and implementing the recommendation will not necessarily mean a favourable outcome.

In comparison with 10-20 years ago we are now able to collect more data per subject than subjects per study. More features imply more information and potentially higher accuracy. Unfortunately an important paradox is that more features we have, the more difficult information extraction with current statistical tools.

A part from quantitative features, non linearity, complexity, fuzzy interaction are new emerging qualitative features of chronic degenerative diseases which account for most morbidity and mortality in western world which hamper accurate prediction in individual patient.

There is now the reason to ask a fundamental question: is the mathematics used in medicine what it should be given the complexity of the chronic degenerative diseases?

The coupling of computer science and these new theoretical bases coming from complex systems mathematics allows the creation of “intelligent” agents able to adapt themselves dynamically to problem of high complexity: the Artificial Adaptive Systems (AAS), which include Artificial Neural Networks( ANN ) and Evolutionary Algorithms ( EA).

AAS are able to reproduce the dynamical interaction of multiple factors simultaneously, allowing the study of complexity.

Our group has proved the usefulness of the added predictive value gained with the use of advanced artificial neural networks coupled with evolutionary algorithms in a number of medical fields, ranging from heart diseases, gastroenterology and neurology with special regard to Alzheimer disease, Cardiovascular diseases and other chronic degenerative disorders.

The philosophy and epistemology of Artificial Adaptive Systems are described in Artificial Adaptive Systems.